Sestrin! The future of exercise?

Imagine, getting fitter, leaner and faster while also slowing down the ageing process. All that, without having to exercise. Could that be possible?


My job is about enhancing people’s performance and health. In essence, I’m trying to help my clients use their time better to maximise results.


During my recent studies, I came across something really interesting: A new protein called Sestrin.


Sestrin is a protein that naturally accumulates in our muscles following exercise.

To understand more about the protein’s link to exercise, Professor Jun Hee Lee, Ph.D. and a team of researchers performed a study on flies and mice. By using a type of fly treadmill, the team trained the flies for three weeks and compared the running and flying ability of normal flies with that of flies bred to lack the ability to make Sestrin.


They noticed the flies with over-expressed Sestrin in their muscles, improved performance, endurance, respiratory ability and even fat burning! In fact, Sestrin improved performance even on the flies that weren’t doing any exercise.


Even more exciting is the fact it could help to slow muscle degeneration and some of the processes we undertake in ageing. Imagine, getting fitter, leaner and faster while also slowing down the ageing process!


Lee also helped another collaborator, Pura Muñoz-Cánoves, Ph.D., of Pompeu Fabra University in Spain, to demonstrate that muscle-specific Sestrin can also help prevent atrophy in a muscle that’s immobilised.

Imagine you have been immobilised due to an accident, injury or serious affliction. Your muscles have atrophied beyond the ability to even work, walk or move. Sestrin has the potential to “simulate exercise” in some way tricking your body into thinking it has exercised so in response your body feels the effects of exercising. WOW!


You must be thinking now.. ‘Where can I buy this?’

Well, this is all very new, Sestrins are not small molecules which makes it hard to just ‘transform’ them into some sort of pill, but scientists will get there.

I reached out to Dr Jun Hee Lee to learn more.
I asked him in my email if his discover could eventually help coma patients and people with degenerative muscle disorders.


Dr. Lee response was: “We continue to focus on further understanding Sestrin action in the exercise and ageing contexts and discovering ways to harness its beneficial activities in body function. Hopefully our future studies can make progress well so that some of it’s product may be helpful for many people. There is certainly more work to be done.”

Well, I’m looking forward to it 🙂

For more information on Sestrins and other aging studies, checkout Dr. Lee’s team Website



With love,


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